World Model · podcast knowledge graph

The Science of MDMA & Its Therapeutic Uses: Benefits & Risks

2023-06-12 · 134 min · episode 128 · 14 entities

episode page audio

Asserted relationships

  • → references Ecstasy book
    0.61 · ×2
    evidence rules-v5
    erman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) MDMA “Ecstasy” (00:04:54) Sponsors: LMNT & Waking Up (00:08:18) MDMA History & Synthesis; Leg
  • → discusses Science concept
    0.40 · ×4
    evidence rules-v4
    Feed category: Science
  • → discusses Health & Fitness concept
    0.40 · ×4
    evidence rules-v4
    Feed category: Health & Fitness
  • → discusses Life Sciences concept
    0.40 · ×4
    evidence rules-v4
    Feed category: Life Sciences
  • → hosted by Scicomm Media company
    0.40 · ×4
    evidence rules-v4
    Feed author/publisher: Scicomm Media
  • → references Hubermanlab​ website
    0.38 · ×4
    evidence rules-v4
    Link in episode "The Science of MDMA & Its Therapeutic Uses: Benefits & Risks": https://drinklmnt.com/hubermanlab

Entities found in this episode

concepts 8

  • mentioned Science concept
    0.50 · ×4
    evidence rules-v4
    Feed category: Science
  • mentioned Health & Fitness concept
    0.50 · ×4
    evidence rules-v4
    Feed category: Health & Fitness
  • mentioned Life Sciences concept
    0.50 · ×4
    evidence rules-v4
    Feed category: Life Sciences
  • mentioned MDMA concept
    0.45 · ×4
    evidence rules-v4
    The Science of MDMA
  • mentioned Benefits & Risks concept
    0.42 · ×4
    evidence rules-v4
    The Science of MDMA & Its Therapeutic Uses: Benefits & Risks
  • discusses Science concept
    0.40 · ×4
    evidence rules-v4
    Feed category: Science
  • discusses Health & Fitness concept
    0.40 · ×4
    evidence rules-v4
    Feed category: Health & Fitness
  • discusses Life Sciences concept
    0.40 · ×4
    evidence rules-v4
    Feed category: Life Sciences

books 2

  • mentioned Ecstasy book
    0.72 · ×2
    evidence rules-v5
    erman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) MDMA “Ecstasy” (00:04:54) Sponsors: LMNT & Waking Up (00:08:18) MDMA History & Synthesis; Leg
  • references Ecstasy book
    0.61 · ×2
    evidence rules-v5
    erman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) MDMA “Ecstasy” (00:04:54) Sponsors: LMNT & Waking Up (00:08:18) MDMA History & Synthesis; Leg

companys 2

  • mentioned Scicomm Media company
    0.70 · ×4
    evidence rules-v4
    Feed author/publisher: Scicomm Media
  • hosted by Scicomm Media company
    0.40 · ×4
    evidence rules-v4
    Feed author/publisher: Scicomm Media

websites 2

  • mentioned Hubermanlab​ website
    0.45 · ×4
    evidence rules-v4
    Link in episode "The Science of MDMA & Its Therapeutic Uses: Benefits & Risks": https://drinklmnt.com/hubermanlab
  • references Hubermanlab​ website
    0.38 · ×4
    evidence rules-v4
    Link in episode "The Science of MDMA & Its Therapeutic Uses: Benefits & Risks": https://drinklmnt.com/hubermanlab
Episode description as stored
In this episode, I discuss Methyl​enedioxy​methamphetamine (MDMA), which is also commonly known as “ecstasy” or “molly,” including how it works in the brain to cause short- and long- term-shifts in emotional processing and its clinical applications for the treatment of post-traumatic stress disorder (PTSD), alcohol and other substance-use addictions. I discuss the neuronal mechanisms for how MDMA elevates mood, empathy, motivation, social engagement, and reduces “threat detection” and how these effects can synergistically support talk therapy. I also explain the ongoing debate about the potential neurotoxicity of MDMA, myths about the origins and treatments for post-MDMA “crash,” the evolving legal landscape around MDMA use for clinical purposes, and I caution recreational users about the extremely dangerous additives (e.g., fentanyl) now commonly found in black market MDMA. This should be of interest to those curious about MDMA, neuropharmacology, the origins of emotional processing in the brain, empathy, PTSD, neuroplasticity, mental health and psychiatry. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1: https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/hubermanlab Waking Up: https://wakingup.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) MDMA “Ecstasy” (00:04:54) Sponsors: LMNT & Waking Up (00:08:18) MDMA History & Synthesis; Legality (00:14:45) MDMA, Methamphetamine (Meth), Dopamine & Serotonin (00:23:30) MDMA vs Psychedelics vs Ketamine (00:26:54) MDMA & Serotonin 1B Receptor, Subjective Feelings, Trauma (00:30:12) Sponsor: AG1 (00:34:51) Amygdala & Threat Detection, Pro-Social Behavior, MDMA Dosages (00:45:48) Interoception, MDMA & Post-Traumatic Stress Disorder (PTSD) (00:52:36) Long-Term Effects, Threat Detection & PTSD (00:56:14) MDMA, Social Connection & Empathy; Meth, SSRIs (01:07:22) Oxytocin & MDMA (01:16:10) Safety & Neurotoxicity; Recreational Use, Caffeine & Fentanyl (01:26:36) Is MDMA Neurotoxic?; Poly-Pharmacology, Body Temperature (01:37:07) Post-MDMA “Crash”, Prolactin & P‑5‑P (01:43:07) PTSD & Trauma; Talk Therapy, SSRIs (01:54:09) PTSD Treatment: Talk Therapy + MDMA (02:02:46) MDMA & Addiction; Dissociative PTSD & Empathy (02:09:47) Side-Effects?, MDMA Efficacy & Legality (02:15:22) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter Disclaimer Learn more about your ad choices. Visit megaphone.fm/adchoices