Coley's Toxins and the Origins of Immunotherapy

2026-09-16 · 38 min · 24 entities

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Feed category: Society & Culture
→ hosted by iHeartPodcasts company

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Feed author/publisher: iHeartPodcasts
→ discusses History website

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Feed category: History
→ references Helen Coley Nauts Advocate For Immunotherapy website

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://circulatingnow.nlm.nih.gov/2016/04/19/helen-coley-nauts-advocate-for-immunotherapy
→ references Cancer Vaccines And Immunotherapy person

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://historyofvaccines.org/vaccines-101/future-immunization/cancer-vaccines-and-immunotherapy
→ references Hall Commotion person

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://archive.nytimes.com/www.nytimes.com/books/first/h/hall-commotion.html
→ references William Coley person

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://oncodaily.com/magazine/william-coley-549446
→ references History Immunotherapy Toxins Targets Cells person

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://labroots.com/trending/cancer/21449/history-immunotherapy-toxins-targets-cells?srsltid=AfmBOooP1eoVP2LbWKR5m-HLu1PSBFhOyPH1jSJWWcxvyK6EA4-hBu47
→ references Immunotherapy Msk person

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://mskcc.org/timeline/immunotherapy-msk
→ references The History Of Immunotherapy person

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://nlm.nih.gov/exhibition/the-history-of-immunotherapy/index.html
→ references Charting The History Of Immunotherapy Cancer Treatments Fourth Pillar website

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://pharmaceutical-technology.com/features/charting-the-history-of-immunotherapy-cancer-treatments-fourth-pillar?cf-closed=&cf-view=
→ references What Ever Happened To Coleys Toxins website

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://cancerresearch.org/blog/what-ever-happened-to-coleys-toxins

Entities found in this episode

persons 12

mentioned Cancer Vaccines And Immunotherapy person

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://historyofvaccines.org/vaccines-101/future-immunization/cancer-vaccines-and-immunotherapy
mentioned Hall Commotion person

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://archive.nytimes.com/www.nytimes.com/books/first/h/hall-commotion.html
mentioned William Coley person

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://oncodaily.com/magazine/william-coley-549446
mentioned History Immunotherapy Toxins Targets Cells person

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://labroots.com/trending/cancer/21449/history-immunotherapy-toxins-targets-cells?srsltid=AfmBOooP1eoVP2LbWKR5m-HLu1PSBFhOyPH1jSJWWcxvyK6EA4-hBu47
mentioned Immunotherapy Msk person

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://mskcc.org/timeline/immunotherapy-msk
mentioned The History Of Immunotherapy person

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://nlm.nih.gov/exhibition/the-history-of-immunotherapy/index.html
references Cancer Vaccines And Immunotherapy person

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://historyofvaccines.org/vaccines-101/future-immunization/cancer-vaccines-and-immunotherapy
references Hall Commotion person

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://archive.nytimes.com/www.nytimes.com/books/first/h/hall-commotion.html
references William Coley person

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://oncodaily.com/magazine/william-coley-549446
references History Immunotherapy Toxins Targets Cells person

0.38

evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://labroots.com/trending/cancer/21449/history-immunotherapy-toxins-targets-cells?srsltid=AfmBOooP1eoVP2LbWKR5m-HLu1PSBFhOyPH1jSJWWcxvyK6EA4-hBu47
references Immunotherapy Msk person

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://mskcc.org/timeline/immunotherapy-msk
references The History Of Immunotherapy person

0.38

evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://nlm.nih.gov/exhibition/the-history-of-immunotherapy/index.html

websites 8

mentioned History website

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evidence rules-v5
Feed category: History
mentioned Helen Coley Nauts Advocate For Immunotherapy website

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://circulatingnow.nlm.nih.gov/2016/04/19/helen-coley-nauts-advocate-for-immunotherapy
mentioned Charting The History Of Immunotherapy Cancer Treatments Fourth Pillar website

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://pharmaceutical-technology.com/features/charting-the-history-of-immunotherapy-cancer-treatments-fourth-pillar?cf-closed=&cf-view=
mentioned What Ever Happened To Coleys Toxins website

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evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://cancerresearch.org/blog/what-ever-happened-to-coleys-toxins
discusses History website

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evidence rules-v5
Feed category: History
references Helen Coley Nauts Advocate For Immunotherapy website

0.38

evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://circulatingnow.nlm.nih.gov/2016/04/19/helen-coley-nauts-advocate-for-immunotherapy
references Charting The History Of Immunotherapy Cancer Treatments Fourth Pillar website

0.38

evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://pharmaceutical-technology.com/features/charting-the-history-of-immunotherapy-cancer-treatments-fourth-pillar?cf-closed=&cf-view=
references What Ever Happened To Coleys Toxins website

0.38

evidence rules-v5
Link in episode "Coley's Toxins and the Origins of Immunotherapy": https://cancerresearch.org/blog/what-ever-happened-to-coleys-toxins

companys 2

mentioned iHeartPodcasts company

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evidence rules-v5
Feed author/publisher: iHeartPodcasts
hosted by iHeartPodcasts company

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evidence rules-v5
Feed author/publisher: iHeartPodcasts

concepts 2

mentioned Society & Culture concept

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evidence rules-v5
Feed category: Society & Culture
discusses Society & Culture concept

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evidence rules-v5
Feed category: Society & Culture

Episode description as stored

William B. Coley started using a bacterial infection to treat cancers in the late 19th century, one of the earliest uses of immunotherapy. Research : Ahuja, Sana and Sufian Zaheer. “The evolution of cancer immunotherapy: a comprehensive review of its history and current perspectives.” Korean Journal of Clinical Oncology 2024; 20(2): 51-73. DOI: https://doi.org/10.14216/kjco.24009 Atkins, Douglas. “Helen Coley Nauts: Advocate for Immunotherapy.” National Library of Medicine. 4/19/2016. https://circulatingnow.nlm.nih.gov/2016/04/19/helen-coley-nauts-advocate-for-immunotherapy/ Cancer Research Institute. “The History of Cancer Immunotherapy.” Coley, William B. “Therapeutic Value of the Mixed Toxins of the Streptococcus of Erysipelas and Bacillus Prodigiosus in the Treatment of Inoperable Malignant Tumors. With a Report of 160 Cases.” American Journal of the Medical Sciences. September 1896. College of Physicians of Philadelphia. “Cancer Vaccines and Immunotherapy.” History of Vaccines. https://historyofvaccines.org/vaccines-101/future-immunization/cancer-vaccines-and-immunotherapy/ Colley, William B. “The Treatment of Inoperable Sarcoma by Bacterial Toxins (the Mixed Toxins of the Streptococcus erysipelas and the Bacillus prodigiosus).” Reprinted from the “ Proceedings of the Royal Society of Medicine,” November, 1909. London. John Bale, Sons & Danielsson, LTD. 1909. https://archive.org/details/b22425949/mode/1up Decker WK, da Silva RF, Sanabria MH, Angelo LS, Guimarães F, Burt BM, Kheradmand F and Paust S (2017) Cancer Immunotherapy: Historical Perspective of a Clinical Revolution and Emerging Preclinical Animal Models. Front. Immunol. 8:829. doi: 10.3389/fimmu.2017.00829 Devaraja, K. et al. “Coley’s Toxin to First Approved Therapeutic Vaccine—A Brief Historical Account in the Progression of Immunobiology-Based Cancer Treatment.” Biomedicines 2024, 12, 2746. https://doi.org/10.3390/biomedicines12122746 Dobosz, Paula and Tomasz Dzieciatkowski.” The Intriguing History of Cancer Immunotherapy. Frontiers in Immunology. 12/17/2019. doi: 10.3389/fimmu.2019.02965 Hall, Stephen S. “A Commotion in the Blood: Life, Death, and the Immune System.” Henry Holt and Company. Excerpted at New York Times. https://archive.nytimes.com/www.nytimes.com/books/first/h/hall-commotion.html Harutyunyan, Mariam. “How William Coley Became The Father of Cancer Immunotherapy.” OncoDaily Magazine. 7/31/2026. https://oncodaily.com/magazine/william-coley-549446 Hiroaki Ikeda, Cancer immunotherapy in progress—an overview of the past 130 years, International Immunology, Volume 37, Issue 5, May 2025, Pages 253–260, https://doi.org/10.1093/intimm/dxaf002 Journal of the American Medical Association. “Erysipelas Toxins in the Treatment of Malignant Tumors.” 10/27/1894. Journal of the American Medical Association. “The Failure of the Erysipelas Toxins.” Vol 23 Iss 24. 12/15/1894. Kokolus, Katie. “The History of Immunotherapy: Toxins, Targets & T Cells.” LabRoots. 10/18/2021. https://www.labroots.com/trending/cancer/21449/history-immunotherapy-toxins-targets-cells?srsltid=AfmBOooP1eoVP2LbWKR5m-HLu1PSBFhOyPH1jSJWWcxvyK6EA4-hBu47 Levine, David B. “The Hospital for the Ruptured and Crippled: William Bradley Coley, third Surgeon-in-Chief 1925-1933.” HSS journal : the musculoskeletal journal of Hospital for Special Surgery vol. 4,1 (2008): 1-9. doi:10.1007/s11420-007-9063-2 McCarthy, Edward F. “The Toxins of William B. Coley and the Treatment of Bone and Soft-tissue Sarcomas.” The Iowa Orthopaedic Journal. Vol. 26. Memorial Sloan Kettering Cancer Center. “MSK Immunotherapy — Timeline of Progress.” https://www.mskcc.org/timeline/immunotherapy-msk National Library of Medicine. “Harnessing the Power of You: The History of Immunotherapy.” https://www.nlm.nih.gov/exhibition/the-history-of-immunotherapy/index.html Nauts, Helen Coley. “Coley’s Toxins – The First Century.” Townsend Letter for Doctors and Patients. June 2004. Nawrat, Allie. “Charting the history of immunothera