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Mast Cells, Histamine, and Perimenopause Explained: MCAS, Anxiety, Estrogen

2026-05-09 · 45 min · 13 entities

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Asserted relationships

  • → discusses Society & Culture concept
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    Feed category: Society & Culture
  • → discusses Health & Fitness concept
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    evidence rules-v5
    Feed category: Health & Fitness
  • → discusses Medicine website
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    Feed category: Medicine
  • → hosted by Audacy | Mary Claire Haver, MD company
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    Feed author/publisher: Audacy | Mary Claire Haver, MD
  • → hosted by Mary Claire Media, LLC company
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    Feed author/publisher: Mary Claire Media, LLC

Entities found in this episode

concepts 6

  • mentioned Society & Culture concept
    0.50
    evidence rules-v5
    Feed category: Society & Culture
  • mentioned Health & Fitness concept
    0.50
    evidence rules-v5
    Feed category: Health & Fitness
  • mentioned MCAS, Anxiety, Estrogen concept
    0.42
    evidence rules-v5
    Mast Cells, Histamine, and Perimenopause Explained: MCAS, Anxiety, Estrogen
  • discusses Society & Culture concept
    0.40
    evidence rules-v5
    Feed category: Society & Culture
  • discusses Health & Fitness concept
    0.40
    evidence rules-v5
    Feed category: Health & Fitness
  • mentioned MCAS concept
    0.35
    evidence rules-v5
    MCAS

companys 4

websites 2

  • mentioned Medicine website
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    evidence rules-v5
    Feed category: Medicine
  • discusses Medicine website
    0.40
    evidence rules-v5
    Feed category: Medicine

books 1

Episode description as stored
In this bonus episode of  unPAUSED , Dr. Mary Claire Haver is joined by Dr. Zachary Rubin, double board certified allergist and immunologist and New York Times bestselling author of  All About Allergies , to dig into the connection between histamine, mast cells, and women's hormonal health. Dr. Rubin breaks down what mast cells are, how histamine works across multiple organ systems, and why women are disproportionately affected by mast cell related conditions including mast cell activation syndrome (MCAS). The two dig into the estrogen and histamine connection, why perimenopause can trigger or worsen symptoms like anxiety, brain fog, and histamine intolerance, and what MCAS actually is and how it is diagnosed. Dr. Rubin also addresses the viral H1 and H2 blocker combination that has been circulating online, explaining the real science behind why it may be helping some women with PMDD, endometriosis, and perimenopausal symptoms, while being honest about what we still do not know. They also cover quercetin, DAO supplements, low histamine diets, and how to think about self experimentation safely. If you have been wondering whether histamine could be a piece of your hormonal health puzzle, this conversation is a great place to start.