World Model · podcast knowledge graph

Why AI Agents Can Beat the Incumbents

2026-10-02 · 60 min · episode 1216 · 19 entities

episode page audio

Asserted relationships

  • → references Seema Amble person
    0.77
    evidence rules-v5
    Link in episode "Why AI Agents Can Beat the Incumbents": https://x.com/seema_amble
  • → references Vladimir Keil person
    0.77
    evidence rules-v5
    Link in episode "Why AI Agents Can Beat the Incumbents": https://linkedin.com/in/vladimir-keil
  • → hosted by Andreessen Horowitz person
    0.55
    evidence rules-v5
    Feed author/publisher: Andreessen Horowitz
  • → discusses Technology company
    0.40
    evidence rules-v5
    Feed category: Technology
  • → discusses Science concept
    0.40
    evidence rules-v5
    Feed category: Science
  • → discusses Business concept
    0.40
    evidence rules-v5
    Feed category: Business
  • → discusses Entrepreneurship concept
    0.40
    evidence rules-v5
    Feed category: Entrepreneurship
  • → hosted by a16z company
    0.40
    evidence rules-v5
    Feed author/publisher: a16z
  • → references lio.ai website
    0.38
    evidence rules-v5
    Link in episode "Why AI Agents Can Beat the Incumbents": https://lio.ai/
  • → references Investing In Lio person
    0.38
    evidence rules-v5
    Link in episode "Why AI Agents Can Beat the Incumbents": https://a16z.com/announcement/investing-in-lio

Entities found in this episode

persons 8

  • mentioned Seema Amble person
    0.90
    evidence rules-v5
    Link in episode "Why AI Agents Can Beat the Incumbents": https://x.com/seema_amble
  • mentioned Vladimir Keil person
    0.90
    evidence rules-v5
    Link in episode "Why AI Agents Can Beat the Incumbents": https://linkedin.com/in/vladimir-keil
  • references Seema Amble person
    0.77
    evidence rules-v5
    Link in episode "Why AI Agents Can Beat the Incumbents": https://x.com/seema_amble
  • references Vladimir Keil person
    0.77
    evidence rules-v5
    Link in episode "Why AI Agents Can Beat the Incumbents": https://linkedin.com/in/vladimir-keil
  • mentioned Andreessen Horowitz person
    0.70
    evidence rules-v5
    Feed author/publisher: Andreessen Horowitz
  • hosted by Andreessen Horowitz person
    0.55
    evidence rules-v5
    Feed author/publisher: Andreessen Horowitz
  • mentioned Investing In Lio person
    0.45
    evidence rules-v5
    Link in episode "Why AI Agents Can Beat the Incumbents": https://a16z.com/announcement/investing-in-lio
  • references Investing In Lio person
    0.38
    evidence rules-v5
    Link in episode "Why AI Agents Can Beat the Incumbents": https://a16z.com/announcement/investing-in-lio

concepts 6

  • mentioned Science concept
    0.50
    evidence rules-v5
    Feed category: Science
  • mentioned Business concept
    0.50
    evidence rules-v5
    Feed category: Business
  • mentioned Entrepreneurship concept
    0.50
    evidence rules-v5
    Feed category: Entrepreneurship
  • discusses Science concept
    0.40
    evidence rules-v5
    Feed category: Science
  • discusses Business concept
    0.40
    evidence rules-v5
    Feed category: Business
  • discusses Entrepreneurship concept
    0.40
    evidence rules-v5
    Feed category: Entrepreneurship

companys 3

  • mentioned Technology company
    0.50
    evidence rules-v5
    Feed category: Technology
  • discusses Technology company
    0.40
    evidence rules-v5
    Feed category: Technology
  • hosted by a16z company
    0.40
    evidence rules-v5
    Feed author/publisher: a16z

websites 2

  • mentioned lio.ai website
    0.45
    evidence rules-v5
    Link in episode "Why AI Agents Can Beat the Incumbents": https://lio.ai/
  • references lio.ai website
    0.38
    evidence rules-v5
    Link in episode "Why AI Agents Can Beat the Incumbents": https://lio.ai/
Episode description as stored
a16z’s Seema Amble and Elena Burger sit down with Lio co-founder and CEO Vladimir Keil to ask where AI-native startups have an advantage when incumbent software companies already own the customer, the data, and the system of record. Their answer comes down to the work that happens outside those systems. In procurement, a final price in an ERP can hide hundreds of emails, spreadsheets, supplier conversations, engineering analyses, and decisions across legal, finance, and operations. Vlad explains how Lio uses multi-agent systems to take on more of that end-to-end work, from sourcing and RFQs to negotiation, shipment tracking, and invoices. They also discuss how enterprises learn to trust agents with increasingly consequential decisions, why the last 20% of an internal AI build can require most of the effort, and what happens when both buyers and suppliers have agents working on their behalf. Resources: Follow Vladimir Keil on X: https://x.com/askvladi?lang=en Follow Vladimir Keil on LinkedIn: https://www.linkedin.com/in/vladimir-keil/ Follow Seema Amble on X: https://x.com/seema_amble Learn more about Lio: https://www.lio.ai/ Seema Amble’s “Investing in Lio” article: https://a16z.com/announcement/investing-in-lio/ Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.