Columbia CS Professor: Why LLMs Can’t Discover New Science

2025-10-13 · 51 min · episode 945 · 16 entities

episode page audio

Asserted relationships

→ references Martin Casado person

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Link in episode "Columbia CS Professor: Why LLMs Can’t Discover New Science": https://x.com/martin_casado
→ references A16z Podcast podcast

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Link in episode "Columbia CS Professor: Why LLMs Can’t Discover New Science": https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711
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Feed author/publisher: a16z

Entities found in this episode

concepts 9

mentioned Science concept

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mentioned Technology concept

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mentioned Business concept

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mentioned Entrepreneurship concept

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mentioned Why LLMs Can’t Discover New Science concept

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Columbia CS Professor: Why LLMs Can’t Discover New Science
discusses Science concept

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discusses Technology concept

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Feed category: Technology
discusses Business concept

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Feed category: Business
discusses Entrepreneurship concept

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Feed category: Entrepreneurship

persons 4

mentioned Martin Casado person

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evidence rules-v4
Link in episode "Columbia CS Professor: Why LLMs Can’t Discover New Science": https://x.com/martin_casado
references Martin Casado person

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evidence rules-v4
Link in episode "Columbia CS Professor: Why LLMs Can’t Discover New Science": https://x.com/martin_casado
mentioned Andreessen Horowitz person

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evidence rules-v4
Feed author/publisher: Andreessen Horowitz
hosted by Andreessen Horowitz person

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evidence rules-v4
Feed author/publisher: Andreessen Horowitz

podcasts 2

mentioned A16z Podcast podcast

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evidence rules-v4
Link in episode "Columbia CS Professor: Why LLMs Can’t Discover New Science": https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711
references A16z Podcast podcast

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evidence rules-v4
Link in episode "Columbia CS Professor: Why LLMs Can’t Discover New Science": https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711

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hosted by a16z company

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Feed author/publisher: a16z

Episode description as stored

From GPT-1 to GPT-5, LLMs have made tremendous progress in modeling human language. But can they go beyond that to make new discoveries and move the needle on scientific progress? We sat down with distinguished Columbia CS professor Vishal Misra to discuss this, plus why chain-of-thought reasoning works so well, what real AGI would look like, and what actually causes hallucinations. Resources: Follow Dr. Misra on X: https://x.com/vishalmisra Follow Martin on X: https://x.com/martin_casado Stay Updated: If you enjoyed this episode, be sure to like, subscribe, and share with your friends! Find a16z on X: https://x.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711 Follow our host: https://x.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.