#184 - AMA #29: GLP-1 Agonists—The Future of Treating Obesity?

2021-11-15 · 14 min · episode 184 · 12 entities

episode page audio

Asserted relationships

→ hosted by Peter Attia, MD person

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Feed author/publisher: Peter Attia, MD
→ discusses Health & Fitness concept

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Feed category: Health & Fitness
→ discusses Medicine concept

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Feed category: Medicine
→ discusses Fitness concept

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Feed category: Fitness

Entities found in this episode

concepts 10

mentioned Health & Fitness concept

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Feed category: Health & Fitness
mentioned Medicine concept

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Feed category: Medicine
mentioned Fitness concept

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Feed category: Fitness
mentioned Treating Obesity concept

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The Future of Treating Obesity
mentioned GLP-1 Agonists—The Future of Treating Obesity concept

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#184 - AMA #29: GLP-1 Agonists—The Future of Treating Obesity?
discusses Health & Fitness concept

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evidence rules-v4
Feed category: Health & Fitness
discusses Medicine concept

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evidence rules-v4
Feed category: Medicine
discusses Fitness concept

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evidence rules-v4
Feed category: Fitness
mentioned AMA concept

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AMA
mentioned GLP concept

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GLP

persons 2

mentioned Peter Attia, MD person

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evidence rules-v4
Feed author/publisher: Peter Attia, MD
hosted by Peter Attia, MD person

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evidence rules-v4
Feed author/publisher: Peter Attia, MD

Episode description as stored

In this "Ask Me Anything" (AMA) episode, Peter and Bob discuss all things related to GLP-1 agonists—a class of drugs that are gaining popularity for the treatment of obesity. They cover the discovery of these peptides, their physiology, and what it is they do in their natural state. Next, Peter and Bob break down a recently published study which showed remarkable results for weight loss and other metabolic parameters using a once-weekly injection of the GLP-1 agonist drug semaglutide, also known as Ozempic, in overweight and obese patients. Finally, they compare results from the semaglutide study to results from various lifestyle interventions and give their take on the potential future of GLP-1 agonists. If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #29 show notes page . If you are not a subscriber, you can learn more about the subscriber benefits here . We discuss: Remarkable results of a recent study in overweight adults [2:15]; Key background on insulin, glucagon and the incretin effect [4:00]; What is GLP-1 and how does it work? [16:30]; 2021 semaglutide study: remarkable results, side effects, and open questions [30:00]; Semaglutide vs. lifestyle interventions: comparing results with semaglutide vs. lifestyle interventions alone [44:00]; Closing thoughts and open questions on the therapeutic potential of semaglutide [47:30]; and More Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/ama29/ Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.