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#27 - David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging

2018-11-05 · 101 min · episode 27 · 10 entities

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  • → hosted by Peter Attia, MD person
    0.55
    evidence rules-v4
    Feed author/publisher: Peter Attia, MD
  • → discusses Health & Fitness concept
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    evidence rules-v4
    Feed category: Health & Fitness
  • → discusses Medicine concept
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    evidence rules-v4
    Feed category: Medicine
  • → discusses Fitness concept
    0.40
    evidence rules-v4
    Feed category: Fitness

Entities found in this episode

concepts 8

  • mentioned Health & Fitness concept
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    evidence rules-v4
    Feed category: Health & Fitness
  • mentioned Medicine concept
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    evidence rules-v4
    Feed category: Medicine
  • mentioned Fitness concept
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    evidence rules-v4
    Feed category: Fitness
  • 0.42
    evidence rules-v4
    #27 - David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging
  • discusses Health & Fitness concept
    0.40
    evidence rules-v4
    Feed category: Health & Fitness
  • discusses Medicine concept
    0.40
    evidence rules-v4
    Feed category: Medicine
  • discusses Fitness concept
    0.40
    evidence rules-v4
    Feed category: Fitness
  • mentioned NAD concept
    0.35
    evidence rules-v4
    NAD

persons 2

  • mentioned Peter Attia, MD person
    0.70
    evidence rules-v4
    Feed author/publisher: Peter Attia, MD
  • hosted by Peter Attia, MD person
    0.55
    evidence rules-v4
    Feed author/publisher: Peter Attia, MD
Episode description as stored
In this episode, David A. Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, provides insight into why we age and how to slow its effects based on his remarkable work on the role of sirtuins and NAD in health and diseases. He also presents the case that stabilizing the epigenetic landscape may be the linchpin in counteracting aging and disease.  We discuss: How and why David moved from Australia to Leonard Guarente's lab at MIT [ 7:30 ]; Sirtuins and aging [ 15:00 ]; A series of experiments elucidating the mechanisms of sirtuins [ 20:45 ]; How are sirtuins activated? [25:30]; NAD and sirtuin activation [31:00]; Nicotinamide, sirtuin inhibition, and PNC1  [39:00]; Resveratrol [43:00]; The NIH/ITP studies on resveratrol [55:45]; Does David take any compounds for longevity? [1:00:15]; NAD precursors (NR, NMN) and pterostilbene [1:02:45]; Female fertility and NAD precursors [1:14:45]; A unifying theory of aging [1:20:30]; Waddington's epigenetic landscape [ 1:23:00 ]; If David had unlimited resources, what is the experiment he would do? [1:28:25]; Testing combinations to extend lifespan [1:31:30]; What made David aware of his mortality at such a young age? [01:33:45]; What is David's book going to cover? [01:37:15]; and More. Learn more at  www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram .