306. The Alzheimer's Drug With a 25% Brain Bleed Risk - Dr. David Perlmutter

You might think Alzheimer's starts in your 70s. Dr. David Perlmutter explains why it begins decades earlier, and how the p-tau 217 blood test flags risk long before symptoms appear. Gary Brecka and Dr. Perlmutter break down microglia, insulin resistance, pre-diabetes, APOE4, homocysteine, vitamin D, creatine and sleep, plus what the POINTER study showed about cognitive decline in metabolically compromised adults. CLICK HERE TO BECOME GARY’S VIP!: https://bit.ly/4ai0Xwg Get Dr. David Perlmutter’s book, “Brain Defenders”: https://bit.ly/4xvoYtY Listen to Dr. David Perlmutter on all your favorite platforms! YouTube: https://bit.ly/46rZjan Spotify: https://bit.ly/4dxPdZl Apple Podcasts: https://bit.ly/4dBz19u Connect with Dr. David Perlmutter Website: https://bit.ly/4yEhBBk YouTube: https://bit.ly/46rZjan Instagram: https://bit.ly/3VgElZH Facebook: https://bit.ly/4xvTC6v TikTok: https://bit.ly/4xXDcEM X: https://bit.ly/4xxJdal LinkedIn: https://bit.ly/4yfpNIF Thank you to our partners A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD AIRES: “ULTIMATE20” FOR 20% OFF: https://bit.ly/4a3Duze BAJA GOLD: “ULTIMATE10” FOR 10% OFF: https://bit.ly/3WSBqUa BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp CYMBIOTIKA: “BRECKACYM30” FOR 30% OFF: https://bit.ly/4tjyluP GENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk GENETIC TEST (USA ONLY): https://bit.ly/3Yg1Uk9 GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC H2TABS: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S PEPTUAL: “TUH10” FOR 10% OFF: https://bit.ly/4mKxgcn SNOOZE: LET’S GET TO SLEEP!: https://bit.ly/4pt1T6V WHOOP: JOIN & GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW Watch the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps 00:00 - Intro of the Show 01:33 - Grain Brain and ultra-processed carbohydrates 03:26 - Pre-diabetes decades before any symptoms 08:03 - Type 3 diabetes and insulin in the brain 11:48 - The fasting insulin level to target 14:08 - Immunometabolism and your microglial cells 16:12 - APOE4 as predisposition, not destiny 19:25 - Inflammation from the gut, mouth and air 25:50 - Aerobic vs resistance training for the brain 30:04 - Sarcopenia, myokines and BDNF 34:44 - Mitochondria and the TSPO brain scan 40:11 - The Tanzi, Ornish and POINTER trials 46:31 - Beta-amyloid drugs and the Cochrane data 55:00 - Sleep, the glymphatic system and insulin 58:25 - Creatine dosing and the creatinine confusion 1:03:52 - Vitamin D, VDR polymorphisms and tau 1:09:35 - Fish oil, DHA and the omega-3 study 1:12:48 - Homocysteine, B complex and MTHFR 1:18:43 - Red light, RNS60 and mitochondrial transplant 1:27:11 - Isolation, cortisol and oxytocin 1:32:58 - What it means to be an ultimate human Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions. Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and ot