#477: Stimulate Don't Suppress: How Natural GLP-1 Hormones Beat Synthetic for Sustainable Fat Loss | Clinical Results With Sarah Kennedy
2026-09-29 · 82 min · 15 entities
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#477: Stimulate Don't Suppress: How Natural GLP-1 Hormones Beat Synthetic for Sustainable Fat Loss | Clinical Results With Sarah Kennedy
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#477: Stimulate Don't Suppress: How Natural GLP-1 Hormones Beat Synthetic for Sustainable Fat Loss | Clinical Results With Sarah Kennedy
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Feed author/publisher: Nathalie Niddam
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Link in episode "#477: Stimulate Don't Suppress: How Natural GLP-1 Hormones Beat Synthetic for Sustainable Fat Loss | Clinical Results With Sarah Kennedy": https://calocurb.com/?sca_ref=12093749.1gzbGYmTyb
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Feed category: Nutrition
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#477: Stimulate Don't Suppress: How Natural GLP-1 Hormones Beat Synthetic for Sustainable Fat Loss | Clinical Results With Sarah Kennedy
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Feed author/publisher: Nathalie Niddam
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#477: Stimulate Don't Suppress: How Natural GLP-1 Hormones Beat Synthetic for Sustainable Fat Loss | Clinical Results With Sarah Kennedy
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Feed author/publisher: Nathalie Niddam
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#477: Stimulate Don't Suppress: How Natural GLP-1 Hormones Beat Synthetic for Sustainable Fat Loss | Clinical Results With Sarah Kennedy
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#477: Stimulate Don't Suppress: How Natural GLP-1 Hormones Beat Synthetic for Sustainable Fat Loss | Clinical Results With Sarah Kennedy
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Link in episode "#477: Stimulate Don't Suppress: How Natural GLP-1 Hormones Beat Synthetic for Sustainable Fat Loss | Clinical Results With Sarah Kennedy": https://calocurb.com/?sca_ref=12093749.1gzbGYmTyb
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evidence rules-v5
Link in episode "#477: Stimulate Don't Suppress: How Natural GLP-1 Hormones Beat Synthetic for Sustainable Fat Loss | Clinical Results With Sarah Kennedy": https://calocurb.com/?sca_ref=12093749.1gzbGYmTyb
Episode description as stored
đź“Ť Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/.
Today, I’m joined by Sarah Kennedy of CaloCurb, a remarkable veterinarian-turned-nutrition expert who brings decades of hands-on research and real-world insight to the weight loss conversation. Sarah shares her unique journey from studying animal nutrition—where performance and health are paramount—to spearheading groundbreaking human clinical trials in appetite regulation, hunger hormones, and innovative, natural GLP-1 strategies.
Learn more about Calocurb at https://www.calocurb.com/?sca_ref=12093749.1gzbGYmTyb and use code NAT for 10% off.
Episode Timestamps:
Welcome and gratitude for listeners ... 00:00:00
Calocurb and GLP-1 context ... 00:02:07
Bitter taste receptors and appetite suppression ... 00:17:13
Discovery of hops as key bitter extract ... 00:20:13
Human trials: hormone changes and calorie reduction ... 00:21:00Comparison to pharmaceutical GLP-1s ... 00:21:44
Appetite studies: women vs. men ... 00:25:15
Recent clinical trial: fat loss, muscle preservation ... 00:28:37
Mechanisms: natural vs. synthetic hormone activation ... 00:31:38
Lasting effects after stopping Calocurb ... 00:34:16
Practical use cases: intermittent fasting, holidays, maintenance ... 00:36:33
Comparison: behavioral effects and food noise ... 00:37:03
Side effects: GI motility, constipation, and laxative effect ... 00:45:03
Calocurb vs. other "GLP-1" supplements ... 00:51:53
Blood sugar effects and limitations ... 00:55:51
Managing late eating and habit change ... 00:59:10
Safety considerations (GI conditions, pregnancy) ... 01:03:23
Older adults, menopause, and ongoing research ... 01:04:50
PYY, muscle satellite cells, and aging ... 01:07:36
Why it's hard to "just use food" for appetite control ... 01:08:41
Coming off pharmaceuticals: rebooting gut-brain axis ... 01:10:25
Open research questions and clinical focus ... 01:12:30
Natural vs. synthetic: critical difference explained ... 01:14:26
Sarah Kennedy's personal experience with food and Calocurb ... 01:16:16
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